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<B>Finding combinatorial biomarkers in AD
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   Lead Investigator:    Vince Grolmusz
   Institution      :    Eotvos University
   E-Mail           :    grolmusz@cs.elte.hu
   Proposal ID      :    193
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>By using advanced datamining tools, including density based clustering and                                                                                          association rule discovery methods, we are searching for biomarkers of the                                                                                          onset and progress of AD. Our biomarkers are the members of a set, and the                                                                                          interrelation of the members of the set are analyzed for pathological roles.                                                                                        Therefore we are looking for                                                                                                                                        onset and monitoring the progression of the disease.                                                                                                                                                                                                                                                                                    The data analyzed include: genetic data, laboratory data, cognitive status,                                                                                         co-morbidity.                                                                                                                                                       Description of his potential data analysis: Suppose that we find from the NACC    data the following relation: ([(TIA5YR .AND. HYPERTEN) .OR. (HYPERCHO)] .AND.     mild impairment in ORIENT .AND. d00241 medication (folic acid supplement)) )      implies fast progression of AD by MMSE and CDR follow-up data. and suppose,       that smaller, simpler relations will not imply the same fast progression, then    we will be able to create a hypothesis that these factors may play a role in      fast progression. A possible hyp </textarea>